.lai-tool{font-family:Source Sans\ 3,Helvetica Neue,sans-serif;max-width:100%}.lai-view-tabs{display:flex;gap:4px;margin-bottom:20px;border-bottom:2px solid var(--border-light,#e8e4dc)}.lai-view-tab{padding:10px 24px;font-family:Source Sans\ 3,sans-serif;font-size:14px;font-weight:600;background:none;border:none;border-bottom:2px solid transparent;margin-bottom:-2px;cursor:pointer;color:var(--text-tertiary,#6a6560);transition:all .2s}.lai-view-tab.active,.lai-view-tab:hover{color:var(--navy,#1b2a4a)}.lai-view-tab.active{border-bottom-color:var(--blue-accent,#2e75b6)}.lai-filters{display:flex;gap:16px;align-items:end;margin-bottom:20px;flex-wrap:wrap}.lai-filter-group{display:flex;flex-direction:column;gap:5px}.lai-filter-label{font-size:11px;font-weight:600;text-transform:uppercase;letter-spacing:.06em;color:var(--blue-accent,#2e75b6)}.lai-filter-select{padding:8px 12px;font-family:Source Sans\ 3,sans-serif;font-size:14px;border:1px solid var(--border-default,#d8d3c8);border-radius:6px;background:var(--bg-card,#fff);color:var(--text-primary,#3a3632);cursor:pointer;-webkit-appearance:auto;-moz-appearance:auto;appearance:auto}.lai-filter-select:focus{outline:none;border-color:var(--blue-accent,#2e75b6);box-shadow:0 0 0 3px rgba(46,117,182,.12)}.lai-filter-count{font-size:13px;color:var(--text-tertiary,#6a6560);padding-bottom:8px}.lai-table-wrap{overflow-x:auto;margin-bottom:24px;border:1px solid var(--border-light,#e8e4dc);border-radius:10px;box-shadow:var(--shadow-sm,0 1px 3px rgba(15,26,46,.06))}.lai-table{border-collapse:collapse;font-size:14px}.lai-th{padding:12px 14px;font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:.06em;color:var(--blue-accent,#2e75b6);background:#fafaf8;border-bottom:2px solid var(--border-light,#e8e4dc);text-align:left;white-space:nowrap}.lai-th-drug{min-width:220px}.lai-th-notes{min-width:240px}.lai-td{padding:12px 14px;border-bottom:1px solid var(--border-light,#e8e4dc);vertical-align:top;line-height:1.5;color:var(--text-primary,#3a3632)}.lai-row:last-child .lai-td{border-bottom:none}.lai-row:hover{background:rgba(46,117,182,.02)}.lai-row.expanded{background:rgba(46,117,182,.03)}.lai-drug-btn{display:flex;align-items:flex-start;gap:6px;background:none;border:none;cursor:pointer;text-align:left;padding:0;font-family:inherit;width:100%}.lai-expand-icon{color:var(--text-tertiary,#6a6560);font-size:12px;margin-top:2px;flex-shrink:0}.lai-generic{display:block;font-weight:600;color:var(--navy,#1b2a4a);font-size:14px;line-height:1.3}.lai-brand{display:block;font-size:13px;color:var(--text-secondary,#7a7568);font-style:italic}.lai-approval{font-size:10px;color:var(--accent-green,#6b8f4a);background:var(--accent-green-bg,rgba(107,143,74,.08));padding:1px 6px;border-radius:3px;margin-top:3px;letter-spacing:.02em}.lai-approval,.lai-interval-badge{display:inline-block;font-weight:600}.lai-interval-badge{padding:4px 8px;border-radius:4px;font-size:12px;background:rgba(46,117,182,.08);color:var(--blue-accent,#2e75b6);white-space:normal;line-height:1.4;max-width:100%}.lai-interval-badge.initio{background:rgba(192,138,48,.1);color:#8a6a20}.lai-td-site{font-size:13px}.lai-site-item{margin-bottom:4px;line-height:1.45}.lai-site-item:last-child{margin-bottom:0}.lai-overlap{font-size:13px;line-height:1.5}.lai-overlap.required{color:#a03030;font-weight:600}.lai-overlap.none{color:var(--accent-green,#6b8f4a)}.lai-td-notes{font-size:13px}.lai-note-item{margin-bottom:6px;line-height:1.5;color:var(--text-secondary,#7a7568)}.lai-note-item:last-child{margin-bottom:0}.lai-more-btn{background:none;border:none;color:var(--blue-accent,#2e75b6);font-size:12px;font-weight:600;cursor:pointer;padding:2px 0;font-family:inherit}.lai-more-btn:hover{text-decoration:underline}.lai-detail-tr{background:transparent}.lai-detail-td{padding:0 14px 14px;border-bottom:1px solid var(--border-light,#e8e4dc);vertical-align:top}.lai-row.expanded .lai-td{border-bottom:none}.lai-detail-panel{margin-top:0;padding:14px 16px;background:#f8f7f4;border-radius:6px;border:1px solid var(--border-light,#e8e4dc)}.lai-detail-row{display:flex;gap:8px;margin-bottom:6px;font-size:13px;line-height:1.5}.lai-detail-row:last-child{margin-bottom:0}.lai-detail-label{font-weight:600;color:var(--navy,#1b2a4a);min-width:120px;flex-shrink:0}.lai-rems-badge{padding:8px 12px;background:#fef0f0;border:1px solid #e0a0a0;border-radius:6px;font-size:13px;font-weight:600;color:#a03030;margin:8px 0}.lai-detail-source{margin-top:8px;font-size:12px;color:var(--text-tertiary,#6a6560);font-style:italic}.lai-conversion{margin-bottom:24px}.lai-conversion-select-wrap{margin-bottom:20px}.lai-conversion-detail{background:var(--bg-card,#fff);border:1px solid var(--border-light,#e8e4dc);border-radius:10px;padding:24px;box-shadow:var(--shadow-md,0 4px 12px rgba(15,26,46,.08))}.lai-conversion-heading{font-family:Playfair Display,Georgia,serif;font-size:22px;font-weight:700;color:var(--navy,#1b2a4a);margin-bottom:20px}.lai-protocol-section{margin-bottom:20px;padding-bottom:16px;border-bottom:1px solid var(--border-light,#e8e4dc)}.lai-protocol-section:last-of-type{border-bottom:none}.lai-protocol-label{font-family:Source Sans\ 3,sans-serif;font-size:12px;font-weight:700;text-transform:uppercase;letter-spacing:.06em;color:var(--blue-accent,#2e75b6);margin-bottom:10px}.lai-protocol-steps{display:flex;flex-direction:column;gap:8px}.lai-protocol-step{display:flex;gap:12px;align-items:baseline;padding:8px 12px;background:#f8f7f4;border-radius:6px;font-size:14px;flex-wrap:wrap}.lai-step-day{font-weight:700;color:var(--navy,#1b2a4a);min-width:60px}.lai-step-dose{font-weight:600;color:var(--text-primary,#3a3632)}.lai-step-site{color:var(--text-secondary,#7a7568);font-size:13px}.lai-step-note{color:var(--text-tertiary,#6a6560);font-size:13px;font-style:italic}.lai-protocol-purpose{font-size:14px;color:var(--text-secondary,#7a7568);line-height:1.6;margin-top:8px}.lai-prerequisite{padding:8px 12px;background:rgba(192,138,48,.08);border-left:3px solid #c08a30;border-radius:0 6px 6px 0;font-size:13px;color:#7a5d20;margin-bottom:12px}.lai-conv-table{width:100%;border-collapse:collapse;font-size:14px;margin-top:8px}.lai-conv-table th{padding:8px 12px;font-size:12px;font-weight:600;text-transform:uppercase;letter-spacing:.04em;color:var(--text-tertiary,#6a6560);background:#fafaf8;border-bottom:1px solid var(--border-light,#e8e4dc);text-align:left}.lai-conv-table td{padding:8px 12px;border-bottom:1px solid var(--border-subtle,#f0ece6);color:var(--text-primary,#3a3632)}.lai-conv-table tr:last-child td{border-bottom:none}.lai-conv-table tr:hover td{background:rgba(46,117,182,.03)}.lai-overlap-detail{padding:10px 14px;border-radius:6px;font-size:14px;line-height:1.6}.lai-overlap-detail.required{background:#fef0f0;border-left:3px solid #a03030;color:#7a2020;font-weight:600}.lai-overlap-detail.none{background:var(--accent-green-bg,rgba(107,143,74,.08));border-left:3px solid var(--accent-green,#6b8f4a);color:#4a6a30}.lai-source-quote{margin-top:16px;padding:12px 16px;background:#f8f7f4;border-left:3px solid var(--border-default,#d8d3c8);border-radius:0 6px 6px 0;font-size:13px;line-height:1.6;color:var(--text-secondary,#7a7568);font-style:italic}.lai-quote-label{font-weight:600;font-style:normal;color:var(--text-primary,#3a3632)}.lai-quote-source{display:block;margin-top:4px;font-size:12px;color:var(--text-tertiary,#6a6560)}.lai-options-grid{display:grid;grid-template-columns:1fr 1fr;grid-gap:12px;gap:12px}.lai-option-card{padding:14px;background:#f8f7f4;border:1px solid var(--border-light,#e8e4dc);border-radius:8px}.lai-option-title{font-size:13px;font-weight:700;color:var(--navy,#1b2a4a);margin-bottom:8px}.lai-option-body{font-size:13px;line-height:1.6;color:var(--text-secondary,#7a7568)}.lai-sources-section{border:1px solid var(--border-light,#e8e4dc);border-radius:8px;overflow:hidden;margin-bottom:16px}.lai-sources-toggle{width:100%;padding:14px 18px;font-family:Source Sans\ 3,sans-serif;font-size:14px;font-weight:600;background:#fafaf8;border:none;text-align:left;cursor:pointer;color:var(--navy,#1b2a4a);transition:background .15s}.lai-sources-toggle:hover{background:#f5f4f1}.lai-sources-body{padding:20px;border-top:1px solid var(--border-light,#e8e4dc)}.lai-sources-heading{font-family:Source Sans\ 3,sans-serif;font-size:13px;font-weight:700;text-transform:uppercase;letter-spacing:.06em;color:var(--blue-accent,#2e75b6);margin:20px 0 10px}.lai-sources-heading:first-child{margin-top:0}.lai-source-entry{margin-bottom:14px;padding-bottom:14px;border-bottom:1px solid var(--border-subtle,#f0ece6)}.lai-source-entry:last-child{margin-bottom:0;padding-bottom:0;border-bottom:none}.lai-source-citation{font-size:14px;line-height:1.5;color:var(--text-primary,#3a3632);margin-bottom:4px}.lai-source-use{font-size:13px;color:var(--text-secondary,#7a7568);font-style:italic;margin-bottom:4px}.lai-pmid-link{color:var(--blue-accent,#2e75b6);text-decoration:none;font-weight:600;font-size:13px}.lai-pmid-link:hover{text-decoration:underline}.lai-critical-note{font-size:14px;line-height:1.6}.lai-critical-note,.lai-disclaimer{color:var(--text-secondary,#7a7568)}.lai-disclaimer{padding:16px 20px;background:#f8f7f4;border:1px solid var(--border-light,#e8e4dc);border-radius:8px;font-size:13px;line-height:1.65;margin-bottom:20px}.lai-disclaimer strong{color:var(--text-primary,#3a3632)}.lai-th-dosing{min-width:260px}.lai-td-dosing{padding:8px 10px!important}.lai-dose-grid{font-size:13px;line-height:1.4}.lai-dose-grid-header{display:flex;gap:6px;font-size:10px;font-weight:700;text-transform:uppercase;letter-spacing:.05em;color:var(--text-tertiary,#6a6560);margin-bottom:4px;padding-bottom:3px;border-bottom:1px solid var(--border-subtle,#f0ece6)}.lai-dose-grid-header span:first-child{min-width:48px}.lai-dose-grid-row{display:flex;align-items:baseline;gap:4px;padding:2px 0;font-size:13px}.lai-dose-grid-row:hover{background:rgba(46,117,182,.04);border-radius:3px}.lai-dose-oral{font-weight:600;color:var(--text-primary,#3a3632);min-width:48px}.lai-dose-arrow{color:var(--text-tertiary,#6a6560);font-size:11px;flex-shrink:0}.lai-dose-lai{font-weight:700;color:var(--navy,#1b2a4a)}.lai-dose-ester{font-weight:400;font-size:11px;color:var(--text-tertiary,#6a6560)}.lai-dose-freq{font-size:11px;color:var(--text-secondary,#7a7568);font-style:italic;margin-left:2px}.lai-dose-rule{font-size:13px;color:var(--text-primary,#3a3632);line-height:1.5;margin-bottom:2px}.lai-dose-range{font-size:11px;color:var(--text-tertiary,#6a6560);margin-top:2px}.lai-dose-avail{font-size:12px;color:var(--text-secondary,#7a7568);margin-top:2px}.lai-dose-prereq{font-size:11px;color:var(--text-tertiary,#6a6560);font-style:italic;margin-top:4px;padding-top:4px;border-top:1px solid var(--border-subtle,#f0ece6)}.lai-loading-block{margin-top:8px;padding-top:8px;border-top:1px dashed var(--border-light,#e8e4dc)}.lai-loading-title{font-size:10px;font-weight:700;text-transform:uppercase;letter-spacing:.05em;color:var(--warning-border,#c4883a);margin-bottom:3px}.lai-loading-step{font-size:12px;line-height:1.5;color:var(--text-primary,#3a3632);margin-bottom:2px}.lai-loading-step strong{color:var(--navy,#1b2a4a)}.lai-loading-window{font-weight:600}.lai-loading-window,.lai-loading-window-note{font-size:11px;color:var(--blue-accent,#2e75b6)}.lai-loading-window-note{margin-top:3px;font-weight:500}.lai-loading-window-note strong{font-weight:700}.lai-detail-notes{margin-top:8px;padding-top:8px;border-top:1px solid var(--border-light,#e8e4dc);display:flex;flex-direction:column;gap:4px}[data-theme=dark] .lai-view-tabs{border-bottom-color:hsla(0,0%,100%,.08)}[data-theme=dark] .lai-view-tab{color:#94a3b8}[data-theme=dark] .lai-view-tab:hover{color:#e2e8f0}[data-theme=dark] .lai-view-tab.active{color:#e2e8f0;border-bottom-color:#38bdf8}[data-theme=dark] .lai-filter-label{color:#38bdf8}[data-theme=dark] .lai-filter-select{background:#1e293b;border-color:hsla(0,0%,100%,.12);color:#e2e8f0}[data-theme=dark] .lai-filter-select:focus{border-color:#38bdf8;box-shadow:0 0 0 3px rgba(56,189,248,.15)}[data-theme=dark] .lai-table-wrap{border-color:hsla(0,0%,100%,.08);box-shadow:0 2px 12px rgba(0,0,0,.3)}[data-theme=dark] .lai-th{background:linear-gradient(135deg,rgba(56,189,248,.08),#1e293b);color:#38bdf8;border-bottom-color:rgba(56,189,248,.2)}[data-theme=dark] .lai-td{border-bottom-color:hsla(0,0%,100%,.06);color:#cbd5e1}[data-theme=dark] .lai-row:hover{background:rgba(56,189,248,.04)}[data-theme=dark] .lai-row.expanded{background:rgba(56,189,248,.06)}[data-theme=dark] .lai-generic{color:#e2e8f0}[data-theme=dark] .lai-brand{color:#94a3b8}[data-theme=dark] .lai-approval{background:rgba(74,222,128,.12);color:#4ade80}[data-theme=dark] .lai-interval-badge{background:rgba(56,189,248,.12);color:#7dd3fc}[data-theme=dark] .lai-interval-badge.initio{background:rgba(251,191,36,.12);color:#fcd34d}[data-theme=dark] .lai-dose-grid-header{color:#64748b;border-bottom-color:hsla(0,0%,100%,.06)}[data-theme=dark] .lai-dose-grid-row:hover{background:rgba(56,189,248,.06)}[data-theme=dark] .lai-dose-oral{color:#cbd5e1}[data-theme=dark] .lai-dose-arrow{color:#475569}[data-theme=dark] .lai-dose-lai{color:#e2e8f0}[data-theme=dark] .lai-dose-ester{color:#64748b}[data-theme=dark] .lai-dose-freq{color:#94a3b8}[data-theme=dark] .lai-dose-rule{color:#cbd5e1}[data-theme=dark] .lai-dose-range{color:#64748b}[data-theme=dark] .lai-dose-avail{color:#94a3b8}[data-theme=dark] .lai-dose-prereq{color:#64748b}[data-theme=dark] .lai-detail-notes,[data-theme=dark] .lai-dose-prereq{border-top-color:hsla(0,0%,100%,.06)}[data-theme=dark] .lai-loading-block{border-top-color:hsla(0,0%,100%,.1)}[data-theme=dark] .lai-loading-title{color:#fbbf24}[data-theme=dark] .lai-loading-step{color:#cbd5e1}[data-theme=dark] .lai-loading-step strong{color:#e2e8f0}[data-theme=dark] .lai-loading-window,[data-theme=dark] .lai-loading-window-note{color:#7dd3fc}[data-theme=dark] .lai-overlap.required{color:#f87171}[data-theme=dark] .lai-overlap.none{color:#4ade80}[data-theme=dark] .lai-detail-td{border-bottom-color:hsla(0,0%,100%,.06)}[data-theme=dark] .lai-detail-panel{background:hsla(0,0%,100%,.04);border-color:hsla(0,0%,100%,.08)}[data-theme=dark] .lai-detail-label{color:#e2e8f0}[data-theme=dark] .lai-rems-badge{background:hsla(0,91%,71%,.1);border-color:hsla(0,91%,71%,.3);color:#f87171}[data-theme=dark] .lai-mini-conversion{border-top-color:hsla(0,0%,100%,.08)}[data-theme=dark] .lai-note-item{color:#94a3b8}[data-theme=dark] .lai-conversion-detail{background:var(--bg-card,#1e293b);border-color:hsla(0,0%,100%,.08);box-shadow:0 4px 16px rgba(0,0,0,.4)}[data-theme=dark] .lai-conversion-heading{color:#e2e8f0}[data-theme=dark] .lai-protocol-section{border-bottom-color:hsla(0,0%,100%,.06)}[data-theme=dark] .lai-protocol-label{color:#38bdf8}[data-theme=dark] .lai-protocol-step{background:hsla(0,0%,100%,.04)}[data-theme=dark] .lai-step-day{color:#e2e8f0}[data-theme=dark] .lai-prerequisite{background:rgba(251,191,36,.08);border-left-color:#fbbf24;color:#fcd34d}[data-theme=dark] .lai-conv-table th{background:hsla(0,0%,100%,.04);color:#94a3b8;border-bottom-color:hsla(0,0%,100%,.08)}[data-theme=dark] .lai-conv-table td{border-bottom-color:hsla(0,0%,100%,.04);color:#cbd5e1}[data-theme=dark] .lai-conv-table tr:hover td{background:rgba(56,189,248,.05)}[data-theme=dark] .lai-overlap-detail.required{background:hsla(0,91%,71%,.08);border-left-color:#f87171;color:#fca5a5}[data-theme=dark] .lai-overlap-detail.none{background:rgba(74,222,128,.08);border-left-color:#4ade80;color:#86efac}[data-theme=dark] .lai-source-quote{background:hsla(0,0%,100%,.04);border-left-color:hsla(0,0%,100%,.12)}[data-theme=dark] .lai-quote-label{color:#e2e8f0}[data-theme=dark] .lai-option-card{background:hsla(0,0%,100%,.04);border-color:hsla(0,0%,100%,.08)}[data-theme=dark] .lai-option-title{color:#e2e8f0}[data-theme=dark] .lai-sources-section{border-color:hsla(0,0%,100%,.08)}[data-theme=dark] .lai-sources-toggle{background:hsla(0,0%,100%,.04);color:#e2e8f0}[data-theme=dark] .lai-sources-toggle:hover{background:hsla(0,0%,100%,.06)}[data-theme=dark] .lai-sources-body{border-top-color:hsla(0,0%,100%,.06)}[data-theme=dark] .lai-source-entry{border-bottom-color:hsla(0,0%,100%,.04)}[data-theme=dark] .lai-disclaimer{background:hsla(0,0%,100%,.04);border-color:hsla(0,0%,100%,.08)}[data-theme=dark] .lai-disclaimer strong{color:#e2e8f0}.lai-table{table-layout:fixed;width:100%}.lai-th-drug{width:20%}.lai-th:nth-child(2){width:15%}.lai-th-dosing{width:34%;min-width:0}.lai-th:nth-child(4){width:18%}.lai-th:nth-child(5){width:13%}.lai-table-wrap{overflow-x:hidden}.lai-td{word-wrap:break-word;overflow-wrap:break-word;-webkit-hyphens:none;hyphens:none}.lai-td-site{font-size:12px;line-height:1.4}@media (max-width:1100px){.lai-td:nth-child(5),.lai-th:nth-child(5){display:none}.lai-th-drug{width:24%}.lai-th:nth-child(2){width:16%}.lai-th-dosing{width:38%}.lai-th:nth-child(4){width:22%}}@media (max-width:900px){.lai-td:nth-child(4),.lai-th:nth-child(4){display:none}.lai-th-drug{width:30%}.lai-th:nth-child(2){width:18%}.lai-th-dosing{width:52%}}@media (max-width:768px){.lai-filters{flex-direction:column;gap:12px}.lai-options-grid{grid-template-columns:1fr}.lai-table-wrap{margin-left:-16px;margin-right:-16px;border-radius:0;border-left:none;border-right:none}.lai-detail-row{flex-direction:column;gap:2px}.lai-detail-label{min-width:auto}.lai-conversion-detail{padding:16px}.lai-th-drug{width:35%}.lai-th:nth-child(2){width:20%}.lai-th-dosing{width:45%}.lai-dose-grid-header span:first-child{min-width:36px}.lai-dose-oral{min-width:36px;font-size:12px}.lai-dose-lai{font-size:12px}.lai-dose-freq{font-size:10px}}