What does the 133-RCT network meta-analysis show about comparative efficacy?

The optimal first-line stimulant depends on the patient's age - a finding that emerges not from efficacy data alone (amphetamine wins on effect size across all ages) but from the tolerability split...

If the first stimulant class doesn't work, what are the chances the other class will?

The optimal first-line stimulant depends on the patient's age - a finding that emerges not from efficacy data alone (amphetamine wins on effect size across all ages) but from the tolerability split...

What does NNT of 2-3 mean for stimulants overall?

The optimal first-line stimulant depends on the patient's age - a finding that emerges not from efficacy data alone (amphetamine wins on effect size across all ages) but from the tolerability split...

Is there a reason to pick one class over the other for a specific patient?

The optimal first-line stimulant depends on the patient's age - a finding that emerges not from efficacy data alone (amphetamine wins on effect size across all ages) but from the tolerability split...

Pharmacology

Should I Start with Methylphenidate or Amphetamine?

Questions this summary answers

Should I start with methylphenidate or amphetamine?
What does the 133-RCT network meta-analysis show about comparative efficacy?
If the first stimulant class doesn't work, what are the chances the other class will?
What does NNT of 2-3 mean for stimulants overall?
Is there a reason to pick one class over the other for a specific patient?

Go Deeper

This summary distills key findings. For the full clinical discussion with complete citations, explore the source lessons.

Primary source

Stimulant MedicationsThe Efficacy Evidence Stimulant MedicationsFormulations & Drug Delivery

Also covered in

ADHD Across the LifespanSchool-Age ADHD: Combined Treatment

Last updated: 2026-04-12

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Should I Start with Methylphenidate or Amphetamine?