Pharmacology
Treatment Resistance and the Systematic Troubleshooting Algorithm
Questions this summary answers
- What's the systematic approach when ADHD medication isn't working?
- When is ADHD considered treatment-resistant?
- What's the DATER troubleshooting framework?
- How often is apparent treatment resistance actually unaddressed comorbidity?
- What's the medication escalation sequence after two stimulant class failures?
- When should I re-evaluate the diagnosis entirely?
Go Deeper
This summary distills key findings. For the full clinical discussion with complete citations, explore the source lessons.
Primary source
Non-Stimulant MedicationsDefining Treatment Resistance + Algorithm Part 1Non-Stimulant MedicationsAlgorithm Part 2, Pregnancy & Non-Stimulant SafetyMonitoring & Long-Term ManagementWhen Treatment Is Not WorkingAlso covered in
Comorbidity IThe Master Clinical AlgorithmLast updated: 2026-04-12