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EVIDENCE-BASED PSYCHIATRY EDUCATION

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Anxiety Disorders Progress

Clinical Tools

1.1 Fear Versus Anxiety: What the Brain Does Differently10 min 1.2 Three Models That Changed the Field7 min 1.3 Neurotransmitter Systems in Anxiety12 min 1.4 Etiology: Genetics, Stress, and Epigenetics15 min 1.5 The DSM-5-TR Framework and Developmental Trajectory14 min 1.6 Clinical Vignettes and Key References16 min ?Chapter Quiz

2.1 The Comprehensive Anxiety Evaluation12 min 2.2 Screening and Assessment Instruments8 min 2.3 The Primary Care Pathway7 min 2.4 Medical Mimics and Substance-Induced Anxiety15 min 2.5 Differential Diagnosis7 min 2.6 Diagnostic Biases and Functional Assessment11 min 2.7 Clinical Vignettes and Key References12 min ?Chapter Quiz

3.1 First-Line Pharmacotherapy: SSRIs and SNRIs18 min 3.2 Benzodiazepines: Mechanism, Evidence, and Bridge Therapy12 min 3.3 Benzodiazepines: Safety, Dependence, and Deprescribing11 min 3.4 Alternative Agents I: Buspirone, Hydroxyzine, and Pregabalin15 min 3.5 Alternative Agents II: Gabapentin, Propranolol, and Mirtazapine8 min 3.6 Alternative Agents III: Trazodone, Alpha-2 Agonists, and Antipsychotics14 min 3.7 What Patients Will Ask About8 min 3.8 Pediatric Anxiety Pharmacotherapy5 min 3.9 Treatment-Resistant Anxiety: Staging, Switching, and Augmentation11 min 3.10 Tricyclic Antidepressants: Practical Prescribing9 min 3.11 MAOIs: The Apex of Anxiolytic Efficacy14 min 3.12 Practical Pharmacotherapy: Selection, Monitoring, and Duration11 min 3.13 Clinical Vignettes and Key References26 min ?Chapter Quiz

4.1 The CBT Evidence Base13 min 4.2 How CBT Works: Mechanisms and Inhibitory Learning11 min 4.3 Exposure Therapy: Principles and Optimization12 min 4.4 Manualized Protocols: Matching Treatment to Patient9 min 4.5 Beyond CBT: ACT, Mindfulness, Psychodynamic, EMDR, and IPT7 min 4.6 Pediatric Psychotherapy and Digital Therapeutics9 min 4.7 Combined Treatment: Medication Plus Psychotherapy13 min 4.8 Engaging the Avoidant Patient and Closing the Therapist Gap8 min 4.9 Clinical Vignettes and Key References27 min ?Chapter Quiz

5.1 Generalized Anxiety Disorder18 min 5.2 Social Anxiety Disorder11 min 5.3 Panic Disorder and Agoraphobia11 min 5.4 Specific Phobias11 min 5.5 Separation Anxiety Disorder Across the Lifespan9 min 5.6 Selective Mutism8 min 5.7 Transdiagnostic vs. Disorder-Specific Treatment6 min 5.8 Clinical Vignettes, Key Takeaways, and Key References25 min ?Chapter Quiz

6.1 Anxiety and Depression: Why They Co-Occur13 min 6.2 Anxiety and Depression: Treating the Comorbid Patient6 min 6.3 Anxiety and ADHD14 min 6.4 Anxiety and OCD12 min 6.5 Anxiety and Trauma/PTSD9 min 6.6 Anxiety and Medical Conditions11 min 6.7 Special Populations: Perinatal Anxiety8 min 6.8 Special Populations: Anxiety in Older Adults8 min 6.9 Sleep, Somatic Presentations, and the System-by-System Guide13 min 6.10 Clinical Vignettes, Key Takeaways, and Key References15 min ?Chapter Quiz

7.1 The Treatment Gap: Who Gets Missed and Why17 min 7.2 The Benzodiazepine Debate: History and the Attribution Problem11 min 7.3 The Benzodiazepine Debate: Guidelines, Deprescribing, and Your Practice9 min 7.4 Emerging Pharmacotherapy14 min 7.5 Digital Therapeutics11 min 7.6 Prevention and the Overtreatment/Undertreatment Paradox16 min 7.7 Clinical Vignettes, Key Takeaways, and Key References21 min ?Chapter Quiz

Evidence Lookup

Audio Tools Printables Tracks Glossary

Lesson 1.4

Etiology: Genetics, Stress, and Epigenetics

15 min read·2,979 words

Where this fits: Anxiety runs in families, but the genetics are polygenic and probabilistic, not deterministic. This lesson covers heritability estimates, the GWAS findings, the cautionary 5-HTTLPR story, behavioral inhibition as a temperamental risk factor, and the HPA axis and epigenetic mechanisms that explain how early life stress alters gene expression.

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