Amphetamine Mixed Salts
Adderall · Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate, and Amphetamine Sulfate
CNS Stimulant (Amphetamine-based)Schedule IIGeneric available
Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. The mode of therapeutic action in ADHD is not known.
Compare Amphetamine Mixed Salts →FDA-Approved Indications
- ADHD (adults; pediatric 6+)
- Narcolepsy (adults; IR formulation)
Common Off-Label Uses
- Narcolepsy
What Sets This Drug Apart
- Mixed amphetamine salts (75% d-amphetamine, 25% l-amphetamine); available in IR (4-6h) and XR (10-12h) formulations
- Among highest efficacy for ADHD in NMA data (Cortese 2018 class-top for amphetamines); first-line in many guidelines
- Highest abuse liability among stimulants (Schedule II); prodrug lisdexamfetamine preferred when diversion is a concern
- Appetite suppression (22% children) and insomnia (17% children) are the top tolerability issues; growth monitoring essential in pediatric patients
- Acidifying agents (ascorbic acid, fruit juice) decrease absorption; alkalinizing agents increase it — counsel on consistent intake
Boxed Warning
ABUSE, MISUSE, AND ADDICTION