Fluphenazine
Prolixin
First-Generation AntipsychoticGeneric availableTDM data
Clinical Pharmacology Fluphenazine hydrochloride has activity at all levels of the central nervous system as well as on multiple organ systems. The mechanism whereby its therapeutic action is exerted is unknown.
Compare Fluphenazine →FDA-Approved Indications
- Management of manifestations of psychotic disorders
Common Off-Label Uses
- Tourette syndrome
What Sets This Drug Apart
- High-potency FGA with minimal sedation and anticholinergic effects; D2 affinity (1.3 nM) more potent per mg than haloperidol
- Available as decanoate LAI (every 2-4 weeks) and enanthate LAI (weekly) — provides flexible long-acting options for adherence-limited patients
- Typical oral doses very low (1-5 mg/day) compared to other FGAs; dose-potency ratio important for switching calculations
- Acute dystonia risk is high, especially in young males; prophylactic benztropine standard within first 72 hours
Boxed Warning
WARNING Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated wit